Gray Matter Correlates of Childhood Maltreatment: Searching for Replicability in a Multi-Cohort Brain-Wide Association Study
Citation:
Goltermann, Janik, Winter, Nils, Meinert, Susanne, Grotegerd, Dominik, Kraus, Anna, Flinkenflügel, Kira, Altegoer, Luisa, Krieger, Judith, Leehr, Elisabeth J., Böhnlein, Joscha, Bonnekoh, Linda M., Richter, Maike, Hahn, Tim, Fisch, Lukas, Gruber, Marius, Hermesdorf, Marco, Berger, Klaus, Arolt, Volker, Brosch, Katharina, Stein, Frederike, Thomas-Odenthal, Florian, Usemann, Paula, Teutenberg, Lea, Hammes, Vincent, Jamalabadi, Hamidreza, Alexander, Nina, Straube, Benjamin, Jansen, Andreas, Nenadić, Igor, Kircher, Tilo, Opel, Nils, Dannlowski, Udo. Gray Matter Correlates of Childhood Maltreatment: Searching for Replicability in a Multi-Cohort Brain-Wide Association Study. bioRxiv. 2025; : 2024.08.15.608132.
Abstract:
Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports have questioned the replicability of mental health neuroimaging findings. Here, we investigate the replicability of gray matter correlates of maltreatment (measured retrospectively via the Childhood Trauma Questionnaire) across three large adult cohorts (total N=3225). Pooling cohorts revealed maltreatment-related gray matter reductions, with most extensive effects when not controlling for depression diagnosis (maximum partial R2=.022). However, none of these effects significantly replicated across cohorts. Non-replicability was consistent across a variety of maltreatment subtypes and operationalizations, as well as subgroup analyses with and without depression, and stratified by sex. In this work we show that there is little evidence for the replicability of gray matter correlates of childhood maltreatment, when adequately controlling for psychopathology. This underscores the need to focus on replicability research in mental health neuroimaging.